PAK4-IN-3

PAK4-IN-3 (compound 27e) is aPAK4inhibitor, with theIC50of 10 nM.PAK4-IN-3shows antiproliferative activity against A549 cells with anIC50value of 0.61μM, and inducesapoptosisof A549 cells in a concentration-dependent manner and blocked the cell cycle at phase G0/G1[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; PAK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pak4-in-3.html

Solubility

10 mM in DMSO

Smiles

N[C@H](C(C)C)CNC(C1=NC2=CC=C(C=C2C(NC3=NNC4=C3C=CC=C4)=N1)Cl)=O

Molecular Formula

C21H22ClN7O

Molecular Weight

423.90

References & Citations

[1]Han W, et al. Design, synthesis and anticancer activity evaluation of 4- (3-1H-indazolyl) amino quinazoline derivatives as PAK4 inhibitors [published online ahead of print, 2023 Oct 13]. Bioorg Med Chem. 2023;95:117501.