PAK4-IN-3
Product Specifications
UNSPSC Description
PAK4-IN-3(compound 27e) is aPAK4inhibitor, with theIC50of 10 nM.PAK4-IN-3shows antiproliferative activity against A549 cells with anIC50value of 0.61μM, and inducesapoptosisof A549 cells in a concentration-dependent manner and blocked the cell cycle at phase G0/G1[1].
Target Antigen
Apoptosis; PAK
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pak4-in-3.html
Solubility
10 mM in DMSO
Smiles
N[C@H](C(C)C)CNC(C1=NC2=CC=C(C=C2C(NC3=NNC4=C3C=CC=C4)=N1)Cl)=O
Molecular Weight
423.90
References & Citations
[1]Han W, et al. Design, synthesis and anticancer activity evaluation of 4-(3-1H-indazolyl)amino quinazoline derivatives as PAK4 inhibitors [published online ahead of print, 2023 Oct 13]. Bioorg Med Chem. 2023;95:117501.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156453/PAK4-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156453/
Clinical Information
No Development Reported
Curated Selection
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