ERK5-IN-6

ERK5-IN-6 (compound 5J) is an ERK5 kinase inhibitor with anticancer activity. ERK5-IN-6 exhibits good anti-proliferative activity with the IC50 value of 4.56 µg/mL for A549 cells[1].

Product Specifications

CAS Number

[2734916-64-2]

UNSPSC

12352005

Target

ERK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/erk5-in-6.html

Solubility

10 mM in DMSO

Smiles

C12=NC=CC=C1C(C3=CCN(CC4=CC=C5C=CC=CC5=C4)CC3)=CN2

Molecular Formula

C23H21N3

Molecular Weight

339.43

References & Citations

[1]Qin Zhang, et al. Design, synthesis and SAR of novel 7-azaindole derivatives as potential Erk5 kinase inhibitor with anticancer activity. Bioorg Med Chem. 2023 Oct 14:95:117503.