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HDAC1/CDK7-IN-1

HDAC1/CDK7-IN-1 (compound 8e) is a dual CDK7 and HDAC1 inhibitor with IC50s of 893 nM and 248 nM, respectively. HDAC1/CDK7-IN-1 inhibits the growth cells of MDA-MB-231, MCF-7, A549, and HCT-116 cancer cells. HDAC1/CDK7-IN-1 induces cell cycle arrest and apoptosis in HCT-116 cells, as well as hindered the migration of HCT-116 cells[1].

Product Specifications

CAS Number

2987905-95-1

UNSPSC

12352005

Target

Apoptosis; CDK; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac1-cdk7-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(NC(CCCCCCC(NO)=O)=O)=CC=C1)NC2=CC(NC3=NC(C4=CNC5=C4C=CC=C5)=C(Cl)C=N3)=CC=C2

Molecular Formula

C33H32ClN7O4

Molecular Weight

626.10

References & Citations

[1]Yao Chen, et al. Discovery of a Dual-Target Inhibitor of CDK7 and HDAC1 That Induces Apoptosis and Inhibits Migration in Colorectal Cancer. ChemMedChem. 2023 Oct 11:e202300281.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK7; HDAC1

Frequently Asked Questions

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