HDAC1/CDK7-IN-1
HDAC1/CDK7-IN-1 (compound 8e) is a dual CDK7 and HDAC1 inhibitor with IC50s of 893 nM and 248 nM, respectively. HDAC1/CDK7-IN-1 inhibits the growth cells of MDA-MB-231, MCF-7, A549, and HCT-116 cancer cells. HDAC1/CDK7-IN-1 induces cell cycle arrest and apoptosis in HCT-116 cells, as well as hindered the migration of HCT-116 cells[1].
Product Specifications
CAS Number
2987905-95-1
UNSPSC
12352005
Target
Apoptosis; CDK; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac1-cdk7-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(NC(CCCCCCC(NO)=O)=O)=CC=C1)NC2=CC(NC3=NC(C4=CNC5=C4C=CC=C5)=C(Cl)C=N3)=CC=C2
Molecular Formula
C33H32ClN7O4
Molecular Weight
626.10
References & Citations
[1]Yao Chen, et al. Discovery of a Dual-Target Inhibitor of CDK7 and HDAC1 That Induces Apoptosis and Inhibits Migration in Colorectal Cancer. ChemMedChem. 2023 Oct 11:e202300281.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK7; HDAC1
Frequently Asked Questions
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