7-51A
7-51A is a potent PB2 inhibitor with a KD value of 1.64 nM as determined by ITC. PB2 is an essential subunit of influenza RNA-dependent RNA polymerase (RdRP) .
Product Specifications
UNSPSC
12352005
Target
Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/7-51a.html
Solubility
10 mM in DMSO
Smiles
COP(OC)(C1=CN=C(N=C1C2=CNC3=C2C=C(C=N3)F)N[C@H]4C5CCC([C@@H]4C(O)=O)CC5)=O
Molecular Formula
C22H25FN5O5P
Molecular Weight
489.44
References & Citations
[1]Weining Sun, et al. Discovery of a potent inhibitor targeting the cap-binding domain of the PB2 subunit of influenza RNA-dependent RNA polymerase. Biochem Biophys Res Commun. 2023 Oct 20:678:97-101.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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