7-51A

7-51A is a potent PB2 inhibitor with a KD value of 1.64 nM as determined by ITC. PB2 is an essential subunit of influenza RNA-dependent RNA polymerase (RdRP) .

Product Specifications

UNSPSC

12352005

Target

Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/7-51a.html

Solubility

10 mM in DMSO

Smiles

COP(OC)(C1=CN=C(N=C1C2=CNC3=C2C=C(C=N3)F)N[C@H]4C5CCC([C@@H]4C(O)=O)CC5)=O

Molecular Formula

C22H25FN5O5P

Molecular Weight

489.44

References & Citations

[1]Weining Sun, et al. Discovery of a potent inhibitor targeting the cap-binding domain of the PB2 subunit of influenza RNA-dependent RNA polymerase. Biochem Biophys Res Commun. 2023 Oct 20:678:97-101.