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DHFR-IN-10

DHFR-IN-10 (compound 4c) is a potent DHFR inhibitor, with an IC50 of 4.21 μM for M. tuberculosis DHFR enzyme. DHFR-IN-10 exhibits potent antituberculosis efficiency[1].

Product Specifications

CAS Number

929484-47-9

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dhfr-in-10.html

Solubility

10 mM in DMSO

Smiles

BrC1=CC=C(C2=CSC(N3N=C(C4=CC=CS4)CC3C5=CC=CS5)=N2)C=C1

Molecular Formula

C20H14BrN3S3

Molecular Weight

472.44

References & Citations

[1]Dawood DH, et, al. New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies. ACS Omega. 2023 Oct 13;8 (42) :39250-39268.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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