BRD9 Degrader-1
BRD9 c-1 (Compound 13-7) is a PROTAC BRD9 degrader[1]. BRD9 Degrader-1 has a micromolar binding affinity for BRD9 and a nanomolar affinity for the BRD9-VCB ternary complex. BRD9 Degrader-1 induces BRD9 proteasome degradation in HEK293T cells, which can be reversed by MLN4924. (Blue: VH032-cyclopropane-F (HY-125905) ; Black: linker (HY-W763939) ; Pink: HY-168695).
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd9-degrader-1.html
Solubility
10 mM in DMSO
Smiles
[H][C@]1([C@@H](CCOC2=CC(C3=C(C)N=CS3)=CC=C2CNC([C@H]4N(C([C@H](C(C)(C)C)NC(C5(CC5)F)=O)=O)C[C@@H](C4)O)=O)[C@]1([H])C6)CN6C7=NC(N(C(C)C)CCNC(C)=O)=NC(N8CC(C8)OC9=NC=CS9)=N7
Molecular Formula
C49H65FN12O7S2
Molecular Weight
1017.25
References & Citations
[1]Liu S, et al. Rational Screening for Cooperativity in Small-Molecule Inducers of Protein-Protein Associations. J Am Chem Soc. 2023 Oct 25;145 (42) :23281-23291.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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