Anti-inflammatory agent 60

Anti-inflammatory agent 60 (compound 21) inhibitsnitric oxide production, with anIC50value of 12.95 μM.Anti-inflammatory agent 60reducesiNOS, phosphorylated p65, andβ-cateninexpression in a concentration-dependent manner[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

NF-κB; NO Synthase; β-catenin

Type

Reference compound

Related Pathways

Immunology/Inflammation; NF-κB; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-60.html

Solubility

10 mM in DMSO

Smiles

CC(C)(C1=CC(C(C)(C)C)=CC(CCC2=CC(O)=CC(O)=C2)=C1)C

Molecular Formula

C22H30O2

Molecular Weight

326.47

References & Citations

[1]Lei M, et al. Design, Synthesis, anti-inflammatory activity Evaluation, preliminary exploration of the Mechanism, molecule Docking, and structure-activity relationship analysis of batatasin III analogs [published online ahead of print, 2023 Oct 16]. Bioorg Med Chem Lett. 2023;96:129527.