RIPK3-IN-4
RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor. RIPK3-IN-4 inhibits HK-2 cell damage, necroptosis and inflammatory responses. RIPK3-IN-4 reduces Cisplatin - and I/R-induced kidney damage, inflammatory response and necroptosis in acute kidney injury[1].
Product Specifications
CAS Number
2304617-58-9
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ripk3-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC(C=CC(OC2=CC=C(F)C(NC(NC3=CC(Br)=CC=C3)=O)=C2)=C4)=C4S1)C5CC5
Molecular Formula
C24H18BrFN4O3S
Molecular Weight
541.39
References & Citations
[1]He XY, et al. Compound-42 alleviates acute kidney injury by targeting RIPK3-mediated necroptosis. Br J Pharmacol. 2023 Oct;180 (20) :2641-2660.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
4921517D22Rik Mouse siRNA Oligo Duplex (Locus ID 70900)