Sec61-IN-5
Sec61-IN-5 (Compound 16c) is a Sec61 inhibitor. Sec61 shows cytotoxicity in A549 cells (IC50: 0.27 nM) . Sec61-IN-5 inhibits Sec61-dependent secretory function (IC50: 0.08 nM) [1].
Product Specifications
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sec61-in-5.html
Solubility
10 mM in DMSO
Smiles
CN(C)[C@H](C(O[C@@H](C(N([C@H](C(N(C)[C@@H](CC(C)C)C(N(C)[C@H](C(N(C)[C@H](C(N(C)[C@@H]([C@@H](C)CC)C(N[C@H](C(N(C)[C@H](C(N[C@H](C1=O)CC2=CC=C(C=C2)C3=CC=CC=C3)=O)CC(C)C)=O)C)=O)=O)COC)=O)[C@H](NC([C@@H](C)N1C)=O)C)=O)=O)COC)C)=O)C(C)C)=O)C(C)C
Molecular Formula
C70H113N11O14
Molecular Weight
1332.71
References & Citations
[1]Suzuki R, et al. Design of Synthetic Surrogates for the Macrolactone Linker Motif in Coibamide A. ACS Med Chem Lett. 2023 Sep 19;14 (10) :1344-1350.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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