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FAK-IN-12

FAK-IN-12 (Compound 12S) is a FAK inhibitor (IC50 = 47 nM) . FAK-IN-12 inhibits MGC-803, HCT-116 and KYSE30 cell proliferation (IC50: 0.24, 0.45, 0.44 μM) . FAK-IN-12 induces apoptosis and cellular senescence[1].

Product Specifications

UNSPSC

12352005

Target

FAK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fak-in-12.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC=C1NC2=C(C=NC(NC3=CC=C(C=C3)/C=C/C(N4CCOCC4)=O)=N2)Cl)NC

Molecular Formula

C25H25ClN6O3

Molecular Weight

492.96

References & Citations

[1]Liu Y, et al. Design, synthesis and biological evaluation of novel 2,4-diaminopyrimidine cinnamyl derivatives as inhibitors of FAK with potent anti-gastric cancer activities. Bioorg Chem. 2023 Sep 30;141:106895.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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