FAK-IN-12
FAK-IN-12 (Compound 12S) is a FAK inhibitor (IC50 = 47 nM) . FAK-IN-12 inhibits MGC-803, HCT-116 and KYSE30 cell proliferation (IC50: 0.24, 0.45, 0.44 μM) . FAK-IN-12 induces apoptosis and cellular senescence[1].
Product Specifications
UNSPSC
12352005
Target
FAK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fak-in-12.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC=C1NC2=C(C=NC(NC3=CC=C(C=C3)/C=C/C(N4CCOCC4)=O)=N2)Cl)NC
Molecular Formula
C25H25ClN6O3
Molecular Weight
492.96
References & Citations
[1]Liu Y, et al. Design, synthesis and biological evaluation of novel 2,4-diaminopyrimidine cinnamyl derivatives as inhibitors of FAK with potent anti-gastric cancer activities. Bioorg Chem. 2023 Sep 30;141:106895.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156334/FAK-IN-12-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156334/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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