NMS-P945
NMS-P945 is an ADC linker that can be used in the synthesis of antibody-drug conjugates (ADCs) . NMS-P945 is suitable for conjugation to mAbs with reproducible Drug Antibody Ratio (DAR) >3.5[1].
Product Specifications
CAS Number
1466546-35-9
UNSPSC
12352203
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nms-p945.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCCCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC2=CC=C(COC(N(C)CCN(C)C(OC(C3=C4C(C)=CS3)=CC5=C4[C@H](CCl)CN5C(C6=CC(C=C(C=C7)OCCN8CCCC8)=C7N6)=O)=O)=O)C=C2)=O)=O)=O)C=CC1=O
Molecular Formula
C61H76ClN11O12S
Molecular Weight
1222.84
References & Citations
[1]Valsasina B, Novel thienoduocarmycin-trastuzumab ADC demonstrates Strong Anti-tumor Efficacy with Favorable Safety Profile in Preclinical Studies. Mol Cancer Ther. 2023 Sep 19.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
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