PARP1-IN-16
PARP1-IN-16 (compound 12a) is a potent PARP1 inhibitor, with an IC50 of 1.89 nM. PARP1-IN-16 can arrest the cell cycle in S phase and induce apoptosis in HCT-116 cells[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp1-in-16.html
Solubility
10 mM in DMSO
Smiles
FC(C=CC(CC1=NNC(C2=CC=CC=C21)=O)=C3)=C3C(N4CCN(CC4)C(CCCO/N=C5/C(NC6=CC=CC=C65)=C7C8=C(NC\7=O)C=CC=C8)=O)=O
Molecular Formula
C40H34FN7O5
Molecular Weight
711.74
References & Citations
[1]Wan S, et, al. Indirubin derivatives as bifunctional molecules inducing DNA damage and targeting PARP for the treatment of cancer. Eur J Med Chem. 2023 Oct 6:261:115843.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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