β5i-IN-1
β5i-IN-1 is a potent and selective inhibitor of β5i with a IC50 of 8.463 nM. β5i-IN-1 releases TNF-α and IL-6 and influences the transcriptional activity of NF-κB. β5i-IN-1 can be used in study idiopathic pulmonary fibrosis[1].
Product Specifications
UNSPSC
12352005
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/β5i-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1N(CCSC)/C(S/C1=C\C2=CC=C(C3=CC=C(B(O)O)C=C3)O2)=N/C4=CC=CN=C4
Molecular Formula
C22H20BN3O4S2
Molecular Weight
465.35
References & Citations
[1]Li Y, et al. Non-peptidic immunoproteasome β5i-selective inhibitor as potential treatment for idiopathic pulmonary fibrosis: Virtual screening, hit evolution and lead identification. Eur J Med Chem. 2023 Dec 5;261:115856.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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