β5i-IN-1

β5i-IN-1 is a potent and selective inhibitor of β5i with a IC50 of 8.463 nM. β5i-IN-1 releases TNF-α and IL-6 and influences the transcriptional activity of NF-κB. β5i-IN-1 can be used in study idiopathic pulmonary fibrosis[1].

Product Specifications

UNSPSC

12352005

Target

Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/β5i-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C1N(CCSC)/C(S/C1=C\C2=CC=C(C3=CC=C(B(O)O)C=C3)O2)=N/C4=CC=CN=C4

Molecular Formula

C22H20BN3O4S2

Molecular Weight

465.35

References & Citations

[1]Li Y, et al. Non-peptidic immunoproteasome β5i-selective inhibitor as potential treatment for idiopathic pulmonary fibrosis: Virtual screening, hit evolution and lead identification. Eur J Med Chem. 2023 Dec 5;261:115856.