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FPR1 antagonist 2

FPR1 antagonist 2 (compound 25b) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 70 nM. FPR1 antagonist 2 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Formyl Peptide Receptor (FPR)

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fpr1-antagonist-2.html

Solubility

10 mM in DMSO

Smiles

CC(OC1=CC2=C(C=C1CCCCCC)C(C(C3=CC=CC(OC)=C3)=C(C(F)(F)F)O2)=O)=O

Molecular Formula

C25H25F3O5

Molecular Weight

462.46

References & Citations

[1]Fabio Francavilla, et al. Development of potent isoflavone-based formyl peptide receptor 1 (FPR1) antagonists and their effects in gastric cancer cell models. Eur J Med Chem. 2023 Oct 4:261:115854.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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