FPR1 antagonist 2
FPR1 antagonist 2 (compound 25b) is a formyl peptide receptor 1 (FPR1) antagonist with an IC50 of 70 nM. FPR1 antagonist 2 inhibits cell growth through a combined effect on cell proliferation and apoptosis and reduces cell migration, while inducing an increase in angiogenesis[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Formyl Peptide Receptor (FPR)
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fpr1-antagonist-2.html
Solubility
10 mM in DMSO
Smiles
CC(OC1=CC2=C(C=C1CCCCCC)C(C(C3=CC=CC(OC)=C3)=C(C(F)(F)F)O2)=O)=O
Molecular Formula
C25H25F3O5
Molecular Weight
462.46
References & Citations
[1]Fabio Francavilla, et al. Development of potent isoflavone-based formyl peptide receptor 1 (FPR1) antagonists and their effects in gastric cancer cell models. Eur J Med Chem. 2023 Oct 4:261:115854.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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