SP4e
SP4e is an activator of PPAR-γ, with the EC50 of 739 nM in HK-2 cells. SP4e reduces the blood glucose levels and lipid peroxidation, and increases glutathione levels and catalase activityin the Swiss albino mice[1].
Product Specifications
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/sp4e.html
Purity
99.72
Solubility
10 mM in DMSO
Smiles
ClC1=CC=CC=C1NC2=CC=C(S2)/C=C(C(N3CC4=CC=C(C=C4)C)=O)\SC3=O
Molecular Formula
C22H17ClN2O2S2
Molecular Weight
440.97
References & Citations
[1]Gupta S, et al. Integrated fragment-based drug design and virtual screening techniques for exploring the antidiabetic potential of thiazolidine-2,4-diones: Design, synthesis and in vivo studies [published online ahead of print, 2023 Sep 21]. Eur J Med Chem. 2023;261:115826.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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