GDI2-IN-1
GDI2-IN-1 (compound (+) -37) is a GDP-dissociation inhibitor beta (GDI2) inhibitor with an IC50 of 2.87 μM and a KD of 36 μM. GDI2-IN-1 exhibits excellent in vivo antitumor activity in GDI2-overexpressing pancreatic xenograft models[1].
Product Specifications
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gdi2-in-1.html
Solubility
10 mM in DMSO
Smiles
O[C@](C[C@@H]1C)(CC2=CN(CC3=CC=C(F)C=C3)N=N2)C[C@@]4([H])N1CCC5=C4C=C(OCC6=CC(C)=CC(C)=C6)C(OCC7=CC(C)=CC(C)=C7)=C5
Molecular Formula
C42H47FN4O3
Molecular Weight
674.85
References & Citations
[1]Yong Sun, et al. Targeting GDP-Dissociation Inhibitor Beta (GDI2) with a Benzo[a]quinolizidine Library to Induce Paraptosis for Cancer Therapy. JACS Au 2023, September 26, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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