BQZ-485

BQZ-485 is a a potent GDI2 inhibitor through the interaction with Tyr245. BQZ-485 disrupts the intrinsic GDI2-Rab1A interaction, thereby abolishing vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus and initiating subsequent paraptosis events[1].

Product Specifications

CAS Number

[1906915-49-8]

UNSPSC

12352005

Target

Paraptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bqz-485.html

Solubility

10 mM in DMSO

Smiles

CC1=CC(C)=CC(COC2=CC3=C([C@](C[C@@H](O)C[C@@H]4C)([H])N4CC3)C=C2OCC5=CC(C)=CC(C)=C5)=C1

Molecular Formula

C32H39NO3

Molecular Weight

485.66

References & Citations

[1]Yong Sun, et al. Targeting GDP-Dissociation Inhibitor Beta (GDI2) with a Benzo[a]quinolizidine Library to Induce Paraptosis for Cancer Therapy. JACS Au 2023, September 26, 2023.