BQZ-485
BQZ-485 is a a potent GDI2 inhibitor through the interaction with Tyr245. BQZ-485 disrupts the intrinsic GDI2-Rab1A interaction, thereby abolishing vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus and initiating subsequent paraptosis events[1].
Product Specifications
CAS Number
[1906915-49-8]
UNSPSC
12352005
Target
Paraptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bqz-485.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(C)=CC(COC2=CC3=C([C@](C[C@@H](O)C[C@@H]4C)([H])N4CC3)C=C2OCC5=CC(C)=CC(C)=C5)=C1
Molecular Formula
C32H39NO3
Molecular Weight
485.66
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156242/BQZ-485-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156242/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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