Meliadubin B
Product Specifications
UNSPSC Description
Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC50 of 5.54 μM). Meliadubin B inhibits inducible nitric oxide synthase. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae with IC50 of 182.50 μM.
Target Antigen
Fungal; NO Synthase
Type
Natural Products
Related Pathways
Anti-infection;Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/meliadubin-b.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1C[C@@]2(C)[C@]([C@](CO1)(C)C(O)=O)(CC=C3[C@]2([H])CC[C@]4(C)[C@]3(C)CC[C@H]4[C@@H](C)CC/C=C(C)\C)[H]
Molecular Weight
472.70
References & Citations
[1]Hieu Tran Trung, et al. Anti-inflammatory and Antiphytopathogenic Fungal Activity of 2,3- seco-Tirucallane Triterpenoids Meliadubins A and B from Melia dubia Cav. Barks with ChemGPS-NP and In Silico Prediction. ACS Omega. 2023 Sep 27;8(40):37116-37127.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156241/Meliadubin-B-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156241/
Clinical Information
No Development Reported
Curated Selection
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