Meliadubin B

Meliadubin B is a natural triterpenoid with significant inflammatory inhibition effect toward superoxide anion generation in human neutrophils (EC50 of 5.54 μM) . Meliadubin B inhibits inducible nitric oxide synthase. Meliadubin B shows remarkable inhibition against the rice pathogenic fungus Magnaporthe oryzae with IC50 of 182.50 μM.

Product Specifications

UNSPSC

12352005

Target

Fungal; NO Synthase

Type

Natural Products

Related Pathways

Anti-infection; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/meliadubin-b.html

Solubility

10 mM in DMSO

Smiles

O[C@@H]1C[C@@]2(C)[C@]([C@](CO1)(C)C(O)=O)(CC=C3[C@]2([H])CC[C@]4(C)[C@]3(C)CC[C@H]4[C@@H](C)CC/C=C(C)\C)[H]

Molecular Formula

C30H48O4

Molecular Weight

472.70

References & Citations

[1]Hieu Tran Trung, et al. Anti-inflammatory and Antiphytopathogenic Fungal Activity of 2,3- seco-Tirucallane Triterpenoids Meliadubins A and B from Melia dubia Cav. Barks with ChemGPS-NP and In Silico Prediction. ACS Omega. 2023 Sep 27;8 (40) :37116-37127.