AChE-IN-41
AChE-IN-41 (Compound 2) is a compound of the Galantamine Memantine hybrid. AChE-IN-41 has the inhibition ability of cholinesterase. AChE-IN-41 shows higher plasma stability and comparable microsomal stability in vitro, while showing lower half-life and faster clearance in vivo[1].
Product Specifications
CAS Number
3038811-77-4
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ache-in-41.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1C=C[C@@]23C(C(CN(C/C=C/CN[C@@]45C[C@]6(C)C[C@@](C5)(C)C[C@@H](C6)C4)CC3)=CC=C7OC)=C7O[C@H]2C1
Molecular Formula
C32H44N2O3
Molecular Weight
504.70
References & Citations
[1]Basagni F, et al. Galantamine-memantine hybrids for Alzheimer's disease: The influence of linker rigidity in biological activity and pharmacokinetic properties. Eur J Med Chem. 2023 Sep 12;261:115803.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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