JNK-IN-14

JNK-IN-14 is a potent JNK inhibitor with IC50 values of 1.81, 12.7 and 10.5 nM for JNK1, JNK2 and JNK3, respectively. JNK-IN-14 induces early-stage apoptosis. JNK-IN-14 shows cell population arrest at the G2/M phase and slightly inhibits beclin-1 production at K562 leukemia cells relative to SP600125 (HY-12041), showing higher inhibitory ability.[1]

Product Specifications

CAS Number

[2991432-56-3]

UNSPSC

12352005

Target

Cytochrome P450; JNK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jnk-in-14.html

Solubility

10 mM in DMSO

Smiles

CC(C)(N1C=C(C(C2=CC(O)=CC=C2)=N1)C3=CC=NC(NCCCNS(=O)(C4=CC=C(C=C4)O)=O)=C3)C

Molecular Formula

C27H31N5O4S

Molecular Weight

521.63

References & Citations

[1] Karim I Mersal, et al. Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.Eur J Med Chem. 2023 Sep 15:261:115779.