HCAIX/XII-IN-8
HCAIX/XII-IN-8 (compound 3g) is a potent human (carbonic anhydrase) CA IX and XII inhibitor, with Ki values of 8.5 and 6.7 nM, respectively. hCAIX/XII-IN-8 shows particularly strong inhibitory activity against the tumor-associated membrane-bound isoforms, hCA IX and XII, while maintaining a high selectivity ratio over cytosolic off-target isoforms hCA I and II[1].
Product Specifications
CAS Number
[59994-64-8]
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaix-xii-in-8.html
Solubility
10 mM in DMSO
Smiles
O=C(N(N=C/1C)C2=CC=C(Cl)C=C2Cl)C1=N\NC(C=C3)=CC=C3S(=O)(N)=O
Molecular Formula
C16H13Cl2N5O3S
Molecular Weight
426.28
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA I; CA IX; CA XII
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