TLR7 agonist 15
TLR7 agonist 15 (compound 16b) is a highly potent TLR7 agonist with an EC50 of 18 nM. TLR7 agonist 15 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations[1].
Product Specifications
CAS Number
2832199-53-6
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-15.html
Solubility
10 mM in DMSO
Smiles
O=C(CCCC)NC1=CC=C(CN2C(CCCC)=NC3=C2C4=C(C=CC=C4)N=C3N)C=C1
Molecular Formula
C26H31N5O
Molecular Weight
429.56
References & Citations
[1]Emma G DeYoung, et al. Synthesis and Optimization of 1-Substituted Imidazo[4,5- c]quinoline TLR7 Agonists. ACS Med Chem Lett. 2023 Sep 14;14 (10) :1358-1368.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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