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TLR7 agonist 14

TLR7 agonist 14 (compound 17b) is a highly potent TLR7 agonist with an EC50 of 18 nM. TLR7 agonist 14 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations[1].

Product Specifications

CAS Number

[2832199-45-6]

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tlr7-agonist-14.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCC(NC1=CC=C(CN2C(CCCC)=NC3=C2C4=C(C=CC=C4)N=C3N)C=C1)=O)OC(C)(C)C

Molecular Formula

C29H36N6O3

Molecular Weight

516.63

References & Citations

[1]Emma G DeYoung, et al. Synthesis and Optimization of 1-Substituted Imidazo[4,5- c]quinoline TLR7 Agonists. ACS Med Chem Lett. 2023 Sep 14;14 (10) :1358-1368.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TLR7

Curated Selection

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