TLR7 agonist 14
Product Specifications
UNSPSC Description
TLR7 agonist 14 (compound 17b) is a highly potent TLR7 agonist with an EC50 of 18 nM. TLR7 agonist 14 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations[1].
Target Antigen
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-14.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCC(NC1=CC=C(CN2C(CCCC)=NC3=C2C4=C(C=CC=C4)N=C3N)C=C1)=O)OC(C)(C)C
Molecular Weight
516.63
References & Citations
[1]Emma G DeYoung, et al. Synthesis and Optimization of 1-Substituted Imidazo[4,5- c]quinoline TLR7 Agonists. ACS Med Chem Lett. 2023 Sep 14;14(10):1358-1368.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156175/TLR7-agonist-14-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156175/
Clinical Information
No Development Reported
CAS Number
2832199-45-6
Curated Selection
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