Thalidomide-NH-PEG6-NH2 (hydrochloride)
Thalidomide-NH-PEG6-NH2 hydrochloride is the Thalidomide (HY-10984) -based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-NH-PEG6-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-nh-peg6-nh2-hydrochloride.html
Purity
99.21
Solubility
10 mM in DMSO
Smiles
O=C1NC(C(CC1)N2C(C3=CC=CC(NCCOCCOCCOCCOCCOCCOCCN)=C3C2=O)=O)=O.Cl
Molecular Formula
C27H41ClN4O10
Molecular Weight
617.09
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
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