Thalidomide-5-NH-PEG5-NH2 (hydrochloride)

Thalidomide-5-NH-PEG5-NH2 hydrochloride is the Thalidomide (HY-10984) -based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-NH-PEG5-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-5-nh-peg5-nh2-hydrochloride.html

Purity

95.84

Solubility

10 mM in DMSO

Smiles

O=C1NC(C(CC1)N2C(C3=CC=C(NCCOCCOCCOCCOCCOCCN)C=C3C2=O)=O)=O.Cl

Molecular Formula

C25H37ClN4O9

Molecular Weight

573.04

References & Citations

[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53. [Content Brief]