HCAIX/XII-IN-7
HCAIX/XII-IN-7 (compound 3e) is a potent hCA IX and XII inhibitor with Kis of 3.2 nM, 9.2 nM, 503.7 nM and 59 nM for hCA I, hCA II, hCA IX and hCA XII, respectively. hCAIX/XII-IN-7 has the potential for hypoxic tumors research[1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaix-xii-in-7.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=C(N(N=C/2C)C(C2=N\NC(C=C3)=CC=C3S(=O)(N)=O)=O)C=C1
Molecular Formula
C17H14N6O3S
Molecular Weight
382.40
References & Citations
[1]Suleyman Akocak, et al. Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides. Bioorg Med Chem Lett. 2023 Oct 15:95:129479.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA I; CA IX; CA XII
Frequently Asked Questions
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