Thalidomide-5-NH-PEG4-NH4 (hydrochloride)
Thalidomide-5-NH-PEG4-NH4 (hydrochloride) is a synthesized compound that incorporates the Thalidomide (HY-14658) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Autophagy; Drug Derivative; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Others; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-5-nh-peg4-nh4-hydrochloride.html
Purity
96.64
Solubility
10 mM in DMSO
Smiles
O=C1NC(C(CC1)N2C(C3=CC=C(NCCOCCOCCOCCOCCN)C=C3C2=O)=O)=O.Cl
Molecular Formula
C23H33ClN4O8
Molecular Weight
528.98
References & Citations
[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53. [Content Brief]
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Curated Selection
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