Thalidomide-5-NH-PEG3-NH2 (hydrochloride)

Thalidomide-5-NH-PEG3-NH2 hydrochloride is a Thalidomide (HY-14658) -based cereblon ligand that recruits CRBN proteins. Thalidomide-5-NH-PEG3-NH2 hydrochloride can be connected to the target protein ligand through a linker to form a PROTAC molecule. For example, THAL-SNS-032 (HY-123937) .

Product Specifications

CAS Number

[2863635-01-0]

UNSPSC

12352005

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-5-nh-peg3-nh2-hydrochloride.html

Purity

98.04

Solubility

10 mM in DMSO

Smiles

O=C1NC(C(CC1)N2C(C3=CC=C(NCCOCCOCCOCCN)C=C3C2=O)=O)=O.Cl

Molecular Formula

C21H29ClN4O7

Molecular Weight

484.93

References & Citations

[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53. [Content Brief]