Thalidomide-5-NH-PEG2-NH2 (hydrochloride)
Thalidomide-5-NH-PEG2-NH2 hydrochloride is a Thalidomide (HY-14658) -based cereblon ligand that recruits CRBN proteins. Thalidomide-5-NH-PEG2-NH2 hydrochloride can be connected to the target protein ligand through a linker to form a PROTAC molecule. For example, THAL-SNS-032 (HY-123937) .
Product Specifications
CAS Number
[2357110-58-6]
UNSPSC
12352005
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-5-nh-peg2-nh2-hydrochloride.html
Purity
96.08
Solubility
10 mM in DMSO
Smiles
O=C1NC(C(CC1)N2C(C3=CC=C(NCCOCCOCCN)C=C3C2=O)=O)=O.Cl
Molecular Formula
C19H25ClN4O6
Molecular Weight
440.88
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
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