CYP51/PD-L1-IN-3
CYP51/PD-L1-IN-3 (compound L21) is a quinazoline compound with antifungal activity. CYP51/PD-L1-IN-3 is a dual inhibitor of CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM), which can induce early apoptosis of fungal cells in the cell cycle. CYP51/PD-L1-IN-3 also significantly reduced intracellular IL-2, NLRP3, and NF-κBp65 protein levels, induced mitochondrial damage and ROS accumulation, and ultimately led to fungal lysis and death[1].
Product Specifications
CAS Number
3032386-59-4
UNSPSC
12352005
Target
Cytochrome P450; Fungal; PD-1/PD-L1
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cyp51-pd-l1-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC2=CC=CC=C2C(N3C=NC=C3)=N1)NC4CCN(C(C5=CC=C(C(C)C)C=C5)=O)CC4
Molecular Formula
C27H28N6O2
Molecular Weight
468.55
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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