NSC194598
NSC194598 is a p53 DNA-binding inhibitor with IC50 value of 180 nM and 2-40 μM for in vitro and in vivo, respectively. NSC194598 interferes with transcriptional activation of mutated RET gene in human medullary thyroid carcinoma TT cells. NSC194598 can be used for acute toxicity to normal tissues by radiation and chemotherapy research[1][2].
Product Specifications
CAS Number
5358-76-9
UNSPSC
12352005
Target
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/nsc194598.html
Purity
98.90
Solubility
DMSO : 8.3 mg/mL (ultrasonic; warming)
Smiles
[O-][N+](C(CN1CCCCC1)=N2)=C3C4=C(C=CC=C4)C5=C3C2=CC=C5
Molecular Formula
C20H19N3O
Molecular Weight
317.38
References & Citations
[1]Li Q, et al. Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity. Oncogene. 2020 Jul;39 (29) :5187-5200.|[2]Shin YJ, et al. Involvement of G-quadruplex structures in regulation of human RET gene expression by small molecules in human medullary thyroid carcinoma TT cells. Oncogene. 2015 Mar 5;34 (10) :1292-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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