Menin-MLL inhibitor 29
Product Specifications
UNSPSC Description
Menin-MLL inhibitor 29 (Compound C1) is a Menin-MLL PPI inhibitor. Menin-MLL inhibitor 29 binds to Menin with a KD value of 138 nM, and inhibits the binding of Menin to MBM1 (Menin-binding motif 1) with an IC50 value of 46 nM. Menin-MLL inhibitor 29 inhibits HepG2 and Hep3B hepatoma cell proliferation (IC50s: 0.31 μM and 0.71 μM). Menin-MLL inhibitor 29 inhibits tumor growth[1].
Target Antigen
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/menin-mll-inhibitor-29.html
Solubility
10 mM in DMSO
Smiles
BrC1=C[C-]([Rh+3]23([C-]4=CC(Br)=CC=C4C5=[N]2C=CC=C5)([N]6=CC=CC7=C6C8=C(C(C)=C7C)C=CC=[N]38)[N]9=C%10C=CC=C9)=C%10C=C1.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
Molecular Weight
922.30
References & Citations
[1]Zhong HJ, et al. Development of an orally bioavailable selective inhibitor of the menin-MLL. Genes Dis. 2022 Oct 18;10(5):1735-1738.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156130/Menin-MLL-inhibitor-29-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156130/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
