Menin-MLL inhibitor 29
Menin-MLL inhibitor 29 (Compound C1) is a Menin-MLL PPI inhibitor. Menin-MLL inhibitor 29 binds to Menin with a KD value of 138 nM, and inhibits the binding of Menin to MBM1 (Menin-binding motif 1) with an IC50 value of 46 nM. Menin-MLL inhibitor 29 inhibits HepG2 and Hep3B hepatoma cell proliferation (IC50s: 0.31 μM and 0.71 μM) . Menin-MLL inhibitor 29 inhibits tumor growth[1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/menin-mll-inhibitor-29.html
Solubility
10 mM in DMSO
Smiles
Molecular Formula
C36H26Br2F6N4PRh
Molecular Weight
922.30
References & Citations
[1]Zhong HJ, et al. Development of an orally bioavailable selective inhibitor of the menin-MLL. Genes Dis. 2022 Oct 18;10 (5) :1735-1738.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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