Menin-MLL inhibitor 29

Menin-MLL inhibitor 29 (Compound C1) is a Menin-MLL PPI inhibitor. Menin-MLL inhibitor 29 binds to Menin with a KD value of 138 nM, and inhibits the binding of Menin to MBM1 (Menin-binding motif 1) with an IC50 value of 46 nM. Menin-MLL inhibitor 29 inhibits HepG2 and Hep3B hepatoma cell proliferation (IC50s: 0.31 μM and 0.71 μM) . Menin-MLL inhibitor 29 inhibits tumor growth[1].

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/menin-mll-inhibitor-29.html

Solubility

10 mM in DMSO

Smiles

BrC1=C[C-]([Rh+3]23([C-]4=CC(Br)=CC=C4C5=[N]2C=CC=C5)([N]6=CC=CC7=C6C8=C(C(C)=C7C)C=CC=[N]38)[N]9=C%10C=CC=C9)=C%10C=C1.[F-][P+5]([F-])([F-])([F-])([F-])[F-]