Sigma-2 Radioligand 1

Sigma-2 Radioligand 1 (compound 1) is a Sigma-2 selective ligand. Sigma-2 Radioligand 1 has good biodistribution in mice and good in vivo activity in rats. [18F] Modified Sigma-2 Radioligand 1 for visualization of tumors in micro-PET/CT imaging, exhibiting high tumor uptake and tumor-to-background ratio. Experiments show that Sigma-2 Radioligand 1 binds highly specifically in U87MG glioma xenografts[1].

Product Specifications

CAS Number

[2860554-32-9]

UNSPSC

12352005

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sigma-2-radioligand-1.html

Solubility

10 mM in DMSO

Smiles

FCCN1C(N(C2=C1C=CC=C2)CCCCN3CCC4=C(C3)C=C(C(OC)=C4)OC)=O

Molecular Formula

C24H30FN3O3

Molecular Weight

427.51

References & Citations

[1]Wang T, et al. Development of a Highly Specific 18F-Labeled Radioligand for Imaging of the Sigma-2 Receptor in Brain Tumors. J Med Chem. 2023 Sep 13.. .