DHFR-IN-8

DHFR-IN-8 (compound 6r) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-8 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=15.6 ng/mL) in mouse models of systemic infection and thigh infection[1].

Product Specifications

CAS Number

[3032441-09-8]

UNSPSC

12352005

Target

Bacterial; Dihydrofolate reductase (DHFR)

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dhfr-in-8.html

Solubility

10 mM in DMSO

Smiles

NC1=NC2=C(C(N)=N1)C(C=CN3CC4=CC=C5SC=NC5=C4)=C3C=C2

Molecular Formula

C18H14N6S

Molecular Weight

346.41

References & Citations

[1]Zhu Z, et al. Exploration and Biological Evaluation of 1, 3-Diamino-7 H-pyrrol [3, 2-f] quinazoline Derivatives as Dihydrofolate Reductase Inhibitors[J]. Journal of Medicinal Chemistry, 2023.. . .