EGFR/CDK2-IN-4
EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor of EGFR and CDK-2 with IC50s of 89.6 and 165.4 nM, respectively. EGFR/CDK2-IN-4 induces apoptosis in MCF-7 cells and arrests the cell cycle in the S phase. EGFR/CDK2-IN-4 has significant anti-cancer cell toxicity and inhibits MCF-7 with an IC50 of 2.74 μM[1].
Product Specifications
UNSPSC
12352005
Target
CDK; EGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-cdk2-in-4.html
Solubility
10 mM in DMSO
Smiles
SC1=NN=C2SCC(C3=NN(C4=CC=CC=C4)C=C3C(C5=CC=C6C=CC=CC6=C5)=O)=NN21
Molecular Formula
C24H16N6OS2
Molecular Weight
468.55
References & Citations
[1]Salem M E, et al. Synthesis and Anti-Breast Cancer Potency of Mono-and Bis- (pyrazolyl [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine) Derivatives as EGFR/CDK-2 Target Inhibitors[J]. ACS Omega, 2023.. . .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
CK-bio-17652-01 48 Tests
Porcine Estrogen Receptor beta, ERb ELISA Kit
Sign In for Pricing
View Details CK-bio-17652-02 96 Tests
Porcine Estrogen Receptor beta, ERb ELISA Kit
Sign In for Pricing
View Details CK-bio-17652-03 5x 96 Tests
Porcine Estrogen Receptor beta, ERb ELISA Kit
Sign In for Pricing
View Details CK-bio-17652-04 10x 96 Tests
Porcine Estrogen Receptor beta, ERb ELISA Kit
Sign In for Pricing
View Details 
KBH8891 1x 96 Well
GENLISA Human Chenodeoxycholic Acid (CDCA) ELISA
Sign In for Pricing
View Details