EGFR/CDK2-IN-4
EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor of EGFR and CDK-2 with IC50s of 89.6 and 165.4 nM, respectively. EGFR/CDK2-IN-4 induces apoptosis in MCF-7 cells and arrests the cell cycle in the S phase. EGFR/CDK2-IN-4 has significant anti-cancer cell toxicity and inhibits MCF-7 with an IC50 of 2.74 μM[1].
Product Specifications
UNSPSC
12352005
Target
CDK; EGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-cdk2-in-4.html
Solubility
10 mM in DMSO
Smiles
SC1=NN=C2SCC(C3=NN(C4=CC=CC=C4)C=C3C(C5=CC=C6C=CC=CC6=C5)=O)=NN21
Molecular Formula
C24H16N6OS2
Molecular Weight
468.55
References & Citations
[1]Salem M E, et al. Synthesis and Anti-Breast Cancer Potency of Mono-and Bis- (pyrazolyl [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine) Derivatives as EGFR/CDK-2 Target Inhibitors[J]. ACS Omega, 2023.. . .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Rabbit Monoclonal Cadherin-17 Antibody (029) [CoraFluor 1]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
NBP2-89891CL1 0.1 mL
Rabbit Monoclonal Cadherin-17 Antibody (029) [CoraFluor 1]
Sign In for Pricing
View Details 
LV629771 1.0 µg DNA
PSME3 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)
Sign In for Pricing
View Details 