EGFR/CDK2-IN-3
EGFR/CDK2-IN-3 (compound 4b) is a dual inhibitor of EGFR and CDK-2 with IC50s of 71.7 and 113.7 nM, respectively. EGFR/CDK2-IN-3 induces apoptosis in MCF-7 cells and arrests the cell cycle in the S phase. EGFR/CDK2-IN-3 has significant anti-cancer cell toxicity and inhibits MCF-7 with an IC50 of 3.16 μM[1].
Product Specifications
UNSPSC
12352005
Target
CDK; EGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-cdk2-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN(C2=CC=CC=C2)N=C1C3=NN4C(SC3)=NN=C4C5=CC=CC=C5)C6=CC=C7C=CC=CC7=C6
Molecular Formula
C30H20N6OS
Molecular Weight
512.58
References & Citations
[1]Salem M E, et al. Synthesis and Anti-Breast Cancer Potency of Mono-and Bis- (pyrazolyl [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine) Derivatives as EGFR/CDK-2 Target Inhibitors[J]. ACS Omega, 2023.. . .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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