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RET-IN-25

RET-IN-25 (compound 6b) is a RET kinase inhibitor with anticancer activity. RET-IN-25 inhibits medullary thyroid carcinoma (MTC) with IC50s of 3.6 μM (3 days) and 3.0 μM (6 days) against TT (C634R) MTC[1].

Product Specifications

CAS Number

2965703-02-8

UNSPSC

12352005

Target

RET

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ret-in-25.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=C(SC2=C1C=NC3=CC=C(C=C32)[N+]([O-])=O)C(OCC)=O)C4=CC=C(C)C=C4

Molecular Formula

C22H17N3O5S

Molecular Weight

435.45

References & Citations

[1]La Monica G, et al. Design and Synthesis of Novel Thieno [3, 2-c] quinoline Compounds with Antiproliferative Activity on RET-Dependent Medullary Thyroid Cancer Cells[J]. ACS Omega, 2023.. . .

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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