PDK-IN-2
PDK-IN-2 (Compound 1F) is a PDK inhibitor (IC50: 68 nM) . PDK-IN-2 inhibits the cellular expression of PDK1 and PDK4. PDK-IN-2 enhances mitochondrial bioenergetics, attenuates glycolytic phenotypes, and induces cell apoptosis in the mitochondrial pathway. PDK-IN-2 inhibits tumor growth in 4T1 syngeneic mice model[1].
Product Specifications
CAS Number
[3032446-61-7]
UNSPSC
12352005
Target
Mitochondrial Metabolism; PDHK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pdk-in-2.html
Solubility
10 mM in DMSO
Smiles
ClC(C(NCCCCCC(NC1=CC=C(C=C1)[As]2SCCCS2)=O)=O)Cl
Molecular Formula
C17H23AsCl2N2O2S2
Molecular Weight
497.33
References & Citations
[1]She W, et al. Reprogramming Energy Metabolism with Synthesized PDK Inhibitors Based on Dichloroacetate Derivatives and Targeted Delivery Systems for Enhanced Cancer Therapy. J Med Chem. 2023 Sep 9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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