PDK-IN-2

PDK-IN-2 (Compound 1F) is a PDK inhibitor (IC50: 68 nM) . PDK-IN-2 inhibits the cellular expression of PDK1 and PDK4. PDK-IN-2 enhances mitochondrial bioenergetics, attenuates glycolytic phenotypes, and induces cell apoptosis in the mitochondrial pathway. PDK-IN-2 inhibits tumor growth in 4T1 syngeneic mice model[1].

Product Specifications

CAS Number

[3032446-61-7]

UNSPSC

12352005

Target

Mitochondrial Metabolism; PDHK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pdk-in-2.html

Solubility

10 mM in DMSO

Smiles

ClC(C(NCCCCCC(NC1=CC=C(C=C1)[As]2SCCCS2)=O)=O)Cl

Molecular Formula

C17H23AsCl2N2O2S2

Molecular Weight

497.33

References & Citations

[1]She W, et al. Reprogramming Energy Metabolism with Synthesized PDK Inhibitors Based on Dichloroacetate Derivatives and Targeted Delivery Systems for Enhanced Cancer Therapy. J Med Chem. 2023 Sep 9.