CaMKIIα-PHOTAC
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) targeting Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) . Molecules such as PHOTAC can catalyze the ubiquitination and degradation of target proteins through the endogenous proteasome under specific wavelengths of light. CaMKIIα-PHOTAC reduces synaptic function under light conditions, and it attenuates the intensity of evoked field excitatory postsynaptic potentials in the mouse hippocampus in response to physiological stimuli. CaMKIIα-PHOTAC plays a critical role in maintaining long-term potentiation and memory capacity in subcellular dendritic domains[1].
Product Specifications
CAS Number
[2481744-33-4]
UNSPSC
12352005
Target
CaMK; PROTACs
Type
Reference compound
Related Pathways
Neuronal Signaling; PROTAC
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/camkiiα-photac.html
Solubility
10 mM in DMSO
Smiles
O=C(COC1=C(OC)C=C(/N=N/C2=CC=CC3=C2CN(C(CC4)C(NC4=O)=O)C3=O)C=C1OC)NCCCCCC(N5CCN(CCCOC6=C(OC)C=C7C(NC8=CC(OC)=C(Cl)C=C8Cl)=C(C#N)C=NC7=C6)CC5)=O
Molecular Formula
C54H58Cl2N10O11
Molecular Weight
1094.00
References & Citations
[1]Ko T, et al. Photoactivated Protein Degrader for Optical Control of Synaptic Function. ACS Chem Neurosci. 2023 Sep 15..
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Browse additional items from our catalog
SEMA6A, CT (Semaphorin-6A, Semaphorin VIA, Sema VIA, Semaphorin-6A-1, SEMA6A-1, KIAA1368, SEMAQ) (MaxLight 750) discontinued
