C-Met-IN-19
C-Met-IN-19 (Compound 21j) is a c-Met inhibitor (IC50: 1.99 nM) . c-Met-IN-19 shows cytotoxicity against A549, HT-29, SGC-7901, MDA-MB-231 cells with IC50s of 0.25, 0.36, 0.98, 0.76 μM[1].
Product Specifications
UNSPSC
12352005
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-met-in-19.html
Solubility
10 mM in DMSO
Smiles
COC1=CC2=C(N=CC=C2OC3=CC=C(NC(CCOC)=NS(=O)(CC4=C(Cl)C=CC=C4Cl)=O)C=C3F)C=C1OCCCN5CCOCC5
Molecular Formula
C34H37Cl2FN4O7S
Molecular Weight
735.65
References & Citations
[1]Nan X, et al. Design, synthesis and biological evaluation of sulfonylamidines as potent c-Met inhibitors by enhancing hydrophobic interaction. Org Biomol Chem. 2023 Sep 20;21 (36) :7459-7466.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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