JMJD3/HDAC-IN-1
Product Specifications
UNSPSC Description
JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HDAC1, IC50=16 nM). JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion[1].
Target Antigen
Apoptosis; HDAC; Histone Demethylase
Type
ADC Related
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/jmjd3-hdac-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(CCCCCNC1=NC(C2=NC=CC=C2)=NC(N3CCCCCC3)=C1)NO
Molecular Weight
398.50
References & Citations
[1]Li A, et al. Design, synthesis and biological evaluation of pyrimidine base hydroxamic acid derivatives as dual JMJD3 and HDAC inhibitors. Bioorg Med Chem Lett. 2023 Oct 1;94:129466.. .
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156094/JMJD3-HDAC-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156094/
Clinical Information
No Development Reported
CAS Number
2883046-06-6
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