JMJD3/HDAC-IN-1

JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HDAC1, IC50=16 nM) . JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion[1].

Product Specifications

CAS Number

[2883046-06-6]

UNSPSC

12352203

Target

Apoptosis; HDAC; Histone Demethylase

Type

ADC Related

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jmjd3-hdac-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(CCCCCNC1=NC(C2=NC=CC=C2)=NC(N3CCCCCC3)=C1)NO

Molecular Formula

C21H30N6O2

Molecular Weight

398.50

References & Citations

[1]Li A, et al. Design, synthesis and biological evaluation of pyrimidine base hydroxamic acid derivatives as dual JMJD3 and HDAC inhibitors. Bioorg Med Chem Lett. 2023 Oct 1;94:129466.. .