PK-10

PK-10 is a synergistic antibacterial agent of Fluconazole and has strong antifungal activity against a variety of Fluconazole-resistant Candida albicans strains. PK-10 combined with Fluconazole can inhibit hyphae formation and induce the accumulation of reactive oxygen species. It further causes damage to mitochondrial membrane potential, reduces intracellular ATP content, and leads to mitochondrial dysfunction[1].

Product Specifications

CAS Number

3074451-41-2

UNSPSC

12352005

Target

Fungal; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pk-10.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(N2CCN(CC2)CC3=CC=C(C(F)(F)F)C=C3)C=C1)/C=C/C4=CC5=C(N=C4N6CCN(CC6)C)C=CC=C5

Molecular Formula

C35H36F3N5O

Molecular Weight

599.69

References & Citations

[1]Sun A, et al. Optimization and antifungal activity of quinoline derivatives linked to chalcone moiety combined with FLC against Candida albicans. Eur J Med Chem. 2023 Nov 15;260:115782.. .