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SSE1806

SSE1806 is a derivative of podophyllotoxin (a natural antimitotic agent) and a microtubule/tubulin inhibitor with significant anticancer and antiproliferative activities. The GI50 of SSE1806 on cancer cell growth ranges from 1.29-21.15 μM. SSE1806 causes mitotic abnormalities and G2/M phase arrest, increases p53 expression, and inhibits colon cancer organoid growth. SSE1806 is able to overcome multidrug resistance in cell lines overexpressing MDR-1[1].

Product Specifications

CAS Number

3053861-26-7

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; Mitosis

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sse1806.html

Solubility

10 mM in DMSO

Smiles

O=C1CCCC2=C1C(C3=CC=CC([N+]([O-])=O)=C3)C4=CC(OCCO5)=C5C=C4N2

Molecular Formula

C21H18N2O5

Molecular Weight

378.38

References & Citations

[1]Firdous F, et al. Design, Synthesis, and Biological Evaluation of SSE1806, a Microtubule Destabilizer That Overcomes Multidrug Resistance[J]. ACS Medicinal Chemistry Letters, 2023...

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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