SSE1806
SSE1806 is a derivative of podophyllotoxin (a natural antimitotic agent) and a microtubule/tubulin inhibitor with significant anticancer and antiproliferative activities. The GI50 of SSE1806 on cancer cell growth ranges from 1.29-21.15 μM. SSE1806 causes mitotic abnormalities and G2/M phase arrest, increases p53 expression, and inhibits colon cancer organoid growth. SSE1806 is able to overcome multidrug resistance in cell lines overexpressing MDR-1[1].
Product Specifications
CAS Number
3053861-26-7
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin; Mitosis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sse1806.html
Solubility
10 mM in DMSO
Smiles
O=C1CCCC2=C1C(C3=CC=CC([N+]([O-])=O)=C3)C4=CC(OCCO5)=C5C=C4N2
Molecular Formula
C21H18N2O5
Molecular Weight
378.38
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Cyclin D1 (CCND1/809), CF647 conjugate, 0.1mg/mL
